Gonadorelin Acetate is a synthetic version of gonadotropin-releasing hormone (GnRH), a naturally occurring hormone responsible for stimulating the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones play essential roles in the reproductive system of both males and females.
Chemical Information
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Chemical Name: Gonadorelin Acetate
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Synonyms: GnRH, LHRH, Gonadotropin-Releasing Hormone
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Molecular Formula: C55H75N17O13 (base form)
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CAS Number: 34973-08-5
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Form: Usually supplied as a lyophilized (freeze-dried) powder for reconstitution
Mechanism of Action
Gonadorelin binds to receptors in the anterior pituitary gland, triggering the secretion of:
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LH (Luteinizing Hormone)
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FSH (Follicle-Stimulating Hormone)
These hormones are crucial for:
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Ovulation in women
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Sperm production in men
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Sex hormone regulation (testosterone, estrogen)
Uses and Applications
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Medical Uses:
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Diagnosis of pituitary function or reproductive hormone disorders
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Treatment of amenorrhea (absence of menstruation)
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Management of infertility related to hypothalamic dysfunction
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Delayed puberty
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Hypogonadotropic hypogonadism (low sex hormone levels due to pituitary or hypothalamic failure)
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Research and Peptide Therapy:
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Used in anti-aging and hormone optimization protocols
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Supports testosterone production in men with suppressed or borderline levels
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May be used in post-cycle therapy (PCT) after anabolic steroid use
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Benefits
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Stimulates natural LH and FSH release
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Promotes testosterone and sperm production in men
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Supports ovulation in women with fertility issues
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Helps maintain pituitary responsiveness
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Useful in hormone replacement and endocrine diagnostics
Dosage and Administration
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Typically administered via subcutaneous (subQ) or intramuscular (IM) injection
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Dosage varies depending on the condition and purpose (clinical vs. performance use)
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Often used in pulse dosing to mimic natural hormone cycles
Always follow a healthcare provider’s instruction for exact dosing.
Possible Side Effects
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Headache
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Nausea
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Abdominal discomfort
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Hot flashes
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Injection site irritation
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Hormonal fluctuations (testosterone/estrogen changes)
Precautions
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Not recommended for individuals with hormone-sensitive cancers
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Requires proper hormonal monitoring
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May interact with other hormone therapies
Storage
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Store lyophilized powder in a cool, dry place
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Once reconstituted, refrigerate and use within the prescribed time frame (usually 7–14 days)




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