AHK-Cu, short for Acetyl Tetrapeptide-3 Copper Complex, is a synthetic peptide bound with copper ions that is gaining popularity in dermatology and cosmetic science, especially in hair regrowth and anti-aging formulations. The peptide is derived from a naturally occurring sequence of amino acids and is designed to stimulate cell regeneration and improve tissue remodeling.
Mechanism of Action
AHK-Cu combines the wound-healing and collagen-boosting benefits of copper ions with the bioactivity of AHK (Acetyl Tetrapeptide-3). When applied to the skin or scalp, this complex:
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Stimulates fibroblast proliferation (cells responsible for collagen and elastin production)
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Promotes angiogenesis (formation of new blood vessels), improving blood flow and nutrient delivery
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Enhances extracellular matrix protein production, such as collagen and laminin
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Strengthens hair follicle anchoring proteins, aiding in hair retention and regrowth
Benefits of AHK-Cu
1. Hair Regrowth
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Encourages anagen phase (growth phase) in hair follicles
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Reduces hair follicle miniaturization
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Strengthens hair strands and improves scalp health
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Commonly used in topical hair serums or mesotherapy
2. Anti-Aging Skin Care
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Reduces fine lines and wrinkles
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Improves skin elasticity and firmness
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Promotes wound healing and skin repair
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Boosts collagen synthesis, supporting younger-looking skin
3. Anti-Inflammatory and Healing
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Copper has inherent anti-inflammatory properties
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Helps in calming irritated or sensitive skin
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Speeds up recovery after cosmetic procedures
Applications
AHK-Cu is primarily found in:
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Hair growth serums
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Microneedling solutions
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Anti-aging facial creams
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Post-procedure recovery products
It is often combined with GHK-Cu (another copper peptide) or minoxidil in hair formulations for enhanced efficacy.
Safety and Side Effects
AHK-Cu is generally well-tolerated in topical applications. Mild irritation can occur in rare cases, especially if used at high concentrations or on sensitive skin. It is advisable to do a patch test before full application.
Conclusion
AHK-Cu is a promising bioactive peptide with regenerative properties that make it effective for hair regrowth, anti-aging, and skin healing. With its dual-action benefits from both peptides and copper ions, it’s a standout ingredient in modern cosmetic science.




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