Semaglutide

Semaglutide is a medication primarily used to treat type 2 diabetes and support weight loss. It belongs to a class of drugs known as GLP-1 receptor agonists (glucagon-like peptide-1), which mimic a natural hormone in the body that helps regulate blood sugar, appetite, and digestion.

How Semaglutide Works

Semaglutide works by:

• Stimulating insulin release when blood sugar levels are high

• Suppressing the release of glucagon (a hormone that raises blood sugar)

• Slowing gastric emptying, which helps you feel full longer

• Reducing appetite, leading to decreased food intake

Common Brand Names

• Ozempic® – Used for type 2 diabetes

• Wegovy® – Approved for chronic weight management

• Rybelsus® – An oral version of Semaglutide for diabetes

Uses

1. Type 2 Diabetes

   • Helps lower blood sugar levels

   • Reduces risk of major cardiovascular events (heart attack, stroke) in diabetic patients

2. Weight Management

   • Aids in significant, sustained weight loss

   • Often prescribed alongside a reduced-calorie diet and increased physical activity

Benefits

• Effective in lowering A1C (average blood sugar over 3 months)

• Promotes weight loss (up to 15% or more of body weight in some clinical trials)

• Once-weekly dosing for injectable versions

• Cardiovascular protection for diabetic patients

Potential Side Effects

• Nausea, vomiting, diarrhea

• Constipation

• Headache or fatigue

• Risk of low blood sugar (especially when combined with other diabetic medications)

• Rare: pancreatitis, gallbladder problems, or thyroid tumors

Important Considerations

• Not recommended for people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

• Must be used under medical supervision

• May interact with other medications